The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression

Rackham, Oliver, Mercer, Timothy R. and Filipovska, Aleksandra (2012) The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression. Wiley Interdisciplinary Reviews. RNA, 3 5: 675-695. doi:10.1002/wrna.1128

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Author Rackham, Oliver
Mercer, Timothy R.
Filipovska, Aleksandra
Title The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression
Journal name Wiley Interdisciplinary Reviews. RNA   Check publisher's open access policy
ISSN 1757-7004
1757-7012
Publication date 2012-07-09
Sub-type Article (original research)
DOI 10.1002/wrna.1128
Open Access Status
Volume 3
Issue 5
Start page 675
End page 695
Total pages 21
Place of publication Oxford, United Kingdom
Publisher John Wiley and Sons
Collection year 2013
Language eng
Formatted abstract
The human mitochondrial transcriptome, although produced from a small and
compact genome, has revealed surprising complexity in its composition and
regulation. Wide variation between individual tRNAs,mRNAs, and rRNAs indicate
the importance of post-transcriptional processing, maturation, and degradation
mechanisms in the regulation of mitochondrial gene expression. RNA-binding
proteins play essential roles in controlling the mitochondrial transcriptome from
its synthesis to its destruction and have evolved unique features to complement the
unusual features of mitochondrial RNAs. Recent studies have shown how changes
in mitochondrial RNAs and their binding proteins can have significant effects on
human health. This opens new avenues for investigation of mitochondrial RNAbinding
proteins and the mechanisms by which they regulate mitochondrial gene
expression.
Keyword Human Mitochondrial-dna
Mitochondrial transcriptome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 9 JUL 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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Created: Wed, 05 Sep 2012, 12:46:53 EST by Susan Allen on behalf of Institute for Molecular Bioscience