Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation

White, M., Murphy, A. J., Hallahan, A., Ware, R. S., Fraser, C. and Davies, P. S. W. (2012) Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation. European Journal of Clinical Nutrition, 66 10: 1120-1123. doi:10.1038/ejcn.2012.109

Author White, M.
Murphy, A. J.
Hallahan, A.
Ware, R. S.
Fraser, C.
Davies, P. S. W.
Title Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation
Journal name European Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0954-3007
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1038/ejcn.2012.109
Volume 66
Issue 10
Start page 1120
End page 1123
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Formatted abstract
Background/objectives: There is a growing body of evidence that nutritional status influences the morbidity and mortality of children undergoing treatment for cancer. The aim of this paper is to determine if nutritional status is associated with survival post-pediatric bone marrow transplant.
Subjects/methods: This was a single-center retrospective audit of patients who underwent an autologous or allogeneic hematopoietic stem cell transplant. Patients were divided into three weight categories of underweight, ideal weight and overweight defined by percent ideal body weight. The outcome of interest, overall post transplant survival, was compared between weight categories.
Results: Of 113 patients, 15 (13%) were underweight and 41 (36%) were classified as overweight. After adjustment for age, sex, donor source, conditioning therapy and year of transplant, overweight patients were significantly less likely to survive than ideal-weight patients (hazard ratio (HR) 1.91; 95% confidence interval, 1.10–3.31). There was no significant increase in mortality when underweight patients were compared with ideal-weight patients (HR 1.47; 95% confidence interval, 0.57–3.79).
Conclusions: Children who are overweight before hematopoietic stem cell transplantation have decreased survival compared with ideal-weight children.
Keyword Hematopoietic stem cell transplant;
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
School of Medicine Publications
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Created: Mon, 03 Sep 2012, 11:47:20 EST by Matthew Lamb on behalf of School of Medicine