Methods and experimental designs for detection of QTL in sheep and goats

van der Werf, Julius H. J., Marshall, Karen and Lee, Sanghong (2007) Methods and experimental designs for detection of QTL in sheep and goats. Small Ruminant Research, 70 1: 21-31. doi:10.1016/j.smallrumres.2007.01.005


Author van der Werf, Julius H. J.
Marshall, Karen
Lee, Sanghong
Title Methods and experimental designs for detection of QTL in sheep and goats
Journal name Small Ruminant Research   Check publisher's open access policy
ISSN 0921-4488
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1016/j.smallrumres.2007.01.005
Volume 70
Issue 1
Start page 21
End page 31
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Methods for detection of quantitative trait loci (QTL) in sheep are discussed. There is a reasonable coverage of the sheep map with microsatellite markers. Developments in molecular genetic technology have now made available very dense marker maps based on single nucleotide polymorphisms, which will soon be available for sheep. Mapping methods were originally based on linkage analysis, either using crosses of divergent breeds or paternal half sib designs in commercial populations. The size of most QTL experiments are too small to allow precise estimation of QTL with moderate effects. Fine mapping is based on linkage disequilibrium (LD) and methods using LD information have now been developed for mapping of QTL. LD analysis can be based on a random sample of animals from the population and is less dependent on marker information and designed experiments.
Keyword Linkage
Linkage disequilibrium
Mapping
Quantitative trait loci
Sheep
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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