AST-induced bone loss in men with prostate cancer: Exercise as a potential countermeasure

Bolam, K. A., Galvão, D. A., Spry, N., Newton, R. U. and Taaffe, D. R. (2012) AST-induced bone loss in men with prostate cancer: Exercise as a potential countermeasure. Prostate Cancer and Prostatic Diseases, 15 4: 329-338. doi:10.1038/pcan.2012.22


Author Bolam, K. A.
Galvão, D. A.
Spry, N.
Newton, R. U.
Taaffe, D. R.
Title AST-induced bone loss in men with prostate cancer: Exercise as a potential countermeasure
Journal name Prostate Cancer and Prostatic Diseases   Check publisher's open access policy
ISSN 1365-7852
1476-5608
Publication date 2012-01-01
Sub-type Article (original research)
DOI 10.1038/pcan.2012.22
Volume 15
Issue 4
Start page 329
End page 338
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Androgen suppression treatment (AST) for men with prostate cancer is associated with a number of treatment-related side effects including an accelerated rate of bone loss. This loss of bone is greatest within the first year of AST and increases the risk for fracture. Pharmaceutical treatment in the form of bisphosphonates is currently used to counter the effects of hormone suppression on bone but is costly and associated with potential adverse effects. Recently, exercise has been shown to be an important adjuvant therapy to manage a range of treatment-related toxicities and enhance aspects of quality of life for men receiving AST. We propose that physical exercise may also have an important role in not only attenuating the bone loss associated with AST but in improving bone health and reducing fracture risk. In this review, the rationale underlying exercise as a countermeasure to AST-induced bone loss is provided.
Keyword Androgen suppression
Bone density
Fracture risk
Physical exercise
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Advance online publication 26 June 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 29 Aug 2012, 21:17:51 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences