Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress

Kim, Hyun Ah, Miller, Alyson A., Drummond, Grant R., Thrift, Amanda G., Arumugam, Thiruma V., Phan, Thanh G., Srikanth, Velandai K. and Sobey, Christopher G. (2012) Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology, 385 10: 953-959.


Author Kim, Hyun Ah
Miller, Alyson A.
Drummond, Grant R.
Thrift, Amanda G.
Arumugam, Thiruma V.
Phan, Thanh G.
Srikanth, Velandai K.
Sobey, Christopher G.
Title Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress
Journal name Naunyn-Schmiedeberg's Archives of Pharmacology   Check publisher's open access policy
ISSN 0028-1298
1432-1912
Publication date 2012
Sub-type Article (original research)
DOI 10.1007/s00210-012-0790-7
Volume 385
Issue 10
Start page 953
End page 959
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract Cerebrovascular disease may lead to a wide range of cognitive changes, referred to collectively as vascular cognitive impairment. Stroke increases the risk of cognitive impairment and dementia, and may contribute to the progression of Alzheimer's disease (AD). Apart from clinical stroke itself, vascular risk factors are associated with the development of cognitive impairment and dementia. Animal models involving a temporary or permanent interruption of blood flow in the common carotid arteries develop nonprogressive cognitive impairment. Oxidative stress during cerebral hypoperfusion in animal models plays a key role in neuronal death and may thus contribute to the development of cognitive impairment in cerebrovascular disease. Genetic and pharmacological interventions to inhibit the major source of reactive oxygen species, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, are neuroprotective in experimental cerebral ischemia. Recent studies have demonstrated that inhibition of NADPH oxidase activity can mitigate cognitive impairment in rodent models of cerebral hypoperfusion. In this article, we review the evidence linking cognitive impairment and/or AD with NADPH oxidase-dependent oxidative stress, including the renin-angiotensin system.
Keyword Alzheimer's disease
Cerebral hypoperfusion
NADPH oxidase
Reactive oxygen species
Vascular cognitive impairment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 8 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Tue, 28 Aug 2012, 21:22:30 EST by Dr Thiruma V Arumugam on behalf of School of Biomedical Sciences