Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress

Kim, Hyun Ah, Miller, Alyson A., Drummond, Grant R., Thrift, Amanda G., Arumugam, Thiruma V., Phan, Thanh G., Srikanth, Velandai K. and Sobey, Christopher G. (2012) Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology, 385 10: 953-959.


Author Kim, Hyun Ah
Miller, Alyson A.
Drummond, Grant R.
Thrift, Amanda G.
Arumugam, Thiruma V.
Phan, Thanh G.
Srikanth, Velandai K.
Sobey, Christopher G.
Title Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress
Journal name Naunyn-Schmiedeberg's Archives of Pharmacology  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012
Sub-type Article
DOI 10.1007/s00210-012-0790-7
Volume number 385
Issue number 10
ISSN 0028-1298
1432-1912
Start page 953
End page 959
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract Cerebrovascular disease may lead to a wide range of cognitive changes, referred to collectively as vascular cognitive impairment. Stroke increases the risk of cognitive impairment and dementia, and may contribute to the progression of Alzheimer's disease (AD). Apart from clinical stroke itself, vascular risk factors are associated with the development of cognitive impairment and dementia. Animal models involving a temporary or permanent interruption of blood flow in the common carotid arteries develop nonprogressive cognitive impairment. Oxidative stress during cerebral hypoperfusion in animal models plays a key role in neuronal death and may thus contribute to the development of cognitive impairment in cerebrovascular disease. Genetic and pharmacological interventions to inhibit the major source of reactive oxygen species, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, are neuroprotective in experimental cerebral ischemia. Recent studies have demonstrated that inhibition of NADPH oxidase activity can mitigate cognitive impairment in rodent models of cerebral hypoperfusion. In this article, we review the evidence linking cognitive impairment and/or AD with NADPH oxidase-dependent oxidative stress, including the renin-angiotensin system.
Keyword Alzheimer's disease
Cerebral hypoperfusion
NADPH oxidase
Reactive oxygen species
Vascular cognitive impairment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 8 August 2012.

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Access Statistics: 17 Abstract Views  -  Detailed Statistics
Created: Tue, 28 Aug 2012, 21:22:30 EST by Dr Thiruma V Arumugam on behalf of School of Biomedical Sciences