Role and potential for therapeutic targeting of MYB in Leukemia

Pattabiraman, D. R. and Gonda, T. J. (2013) Role and potential for therapeutic targeting of MYB in Leukemia. Leukemia, 27 2: 269-277. doi:10.1038/leu.2012.225


Author Pattabiraman, D. R.
Gonda, T. J.
Title Role and potential for therapeutic targeting of MYB in Leukemia
Formatted title
Role and potential for therapeutic targeting of MYB in Leukemia
Journal name Leukemia   Check publisher's open access policy
ISSN 0887-6924
1476-5551
Publication date 2013
Year available 2012
Sub-type Article (original research)
DOI 10.1038/leu.2012.225
Open Access Status
Volume 27
Issue 2
Start page 269
End page 277
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract The Myb protein was first identified as an oncogene that causes leukemia in chickens. Since then, it has been widely associated with different types of cancers and studied in detail in myeloid leukemias. However, despite these studies, its role in the induction, pathogenesis and maintenance of AML, and other blood disorders, is still not well understood. Recent efforts to uncover its plethora of transcriptional targets have provided key insights into understanding its mechanism of action. This review evaluates our current knowledge of the role of Myb in leukemia, with a particular focus on AML, from the vast literature spanning three decades, highlighting key studies that have influenced our understanding.We discuss recent insights intoits role in leukemogenesis and how these could be exploited for the therapeutic targeting of Myb, its associated co-regulators or its target genes,in order to improve outcomes in the treatment of a wide range of hematopoietic malignancies.
Keyword Myb
Targeting
Leukemia
p300
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted article preview online 9 August 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Pharmacy Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 27 Aug 2012, 10:53:01 EST by Myrtle Sahabandu on behalf of School of Pharmacy