Calcium channels and pumps in cancer: changes and consequences

Monteith, Gregory R., Davis, Felicity M. and Roberts-Thomson, Sarah J. (2012) Calcium channels and pumps in cancer: changes and consequences. Journal of Biological Chemistry, 287 38: 31666-31673. doi:10.1074/jbc.R112.343061


Author Monteith, Gregory R.
Davis, Felicity M.
Roberts-Thomson, Sarah J.
Title Calcium channels and pumps in cancer: changes and consequences
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2012-09-14
Sub-type Article (original research)
DOI 10.1074/jbc.R112.343061
Volume 287
Issue 38
Start page 31666
End page 31673
Total pages 15
Place of publication Bethesda, MD United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2013
Language eng
Formatted abstract Increases in intracellular free Ca2+ play a major role in many cellular processes. The
deregulation of Ca2+ signaling is a feature of a variety of diseases and modulators of Ca2+ signaling are used to treat conditions as diverse as hypertension to pain. The Ca2+ signal also plays a role in processes important in cancer such as proliferation and migration.  Many studies in cancer have identified alterations in the expression of proteins involved in the movement of Ca2+ across the plasma membrane and sub-cellular organelles. In some cases these Ca2+ channels or pumps are potential therapeutic targets for specific cancer subtypes or correlate with prognosis.
Keyword Calcium
Cancer
Calcium-ATPases
Calcium channels
Open Access Mandate Compliance Yes - Open Access (Publisher DOI)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Pharmacy Publications
 
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Created: Fri, 24 Aug 2012, 15:05:55 EST by Myrtle Sahabandu on behalf of School of Pharmacy