Calcium channels and pumps in cancer: changes and consequences

Monteith, Gregory R., Davis, Felicity M. and Roberts-Thomson, Sarah J. (2012) Calcium channels and pumps in cancer: changes and consequences. Journal of Biological Chemistry, 287 38: 31666-31673.


Author Monteith, Gregory R.
Davis, Felicity M.
Roberts-Thomson, Sarah J.
Title Calcium channels and pumps in cancer: changes and consequences
Journal name Journal of Biological Chemistry  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2012-09-14
Sub-type Article
DOI 10.1074/jbc.R112.343061
Volume number 287
Issue number 38
ISSN 0021-9258
Start page 31666
End page 31673
Total pages 15
Place of publication Bethesda, MD United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2013
Language eng
Formatted abstract Increases in intracellular free Ca2+ play a major role in many cellular processes. The
deregulation of Ca2+ signaling is a feature of a variety of diseases and modulators of Ca2+ signaling are used to treat conditions as diverse as hypertension to pain. The Ca2+ signal also plays a role in processes important in cancer such as proliferation and migration.  Many studies in cancer have identified alterations in the expression of proteins involved in the movement of Ca2+ across the plasma membrane and sub-cellular organelles. In some cases these Ca2+ channels or pumps are potential therapeutic targets for specific cancer subtypes or correlate with prognosis.
Keyword Calcium
Cancer
Calcium-ATPases
Calcium channels
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
School of Pharmacy Publications
 
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Created: Fri, 24 Aug 2012, 15:05:55 EST by Myrtle Sahabandu on behalf of School of Pharmacy