Development and evaluation of a standardised pathway for clozapine use in treatment resistant schizophrenia in institutionalised patients

Ally, Bashir A.S. (2011). Development and evaluation of a standardised pathway for clozapine use in treatment resistant schizophrenia in institutionalised patients Master's Thesis, School of Pharmacy, The University of Queensland.

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Author Ally, Bashir A.S.
Thesis Title Development and evaluation of a standardised pathway for clozapine use in treatment resistant schizophrenia in institutionalised patients
School, Centre or Institute School of Pharmacy
Institution The University of Queensland
Publication date 2011-05
Thesis type Master's Thesis
Supervisor Helen Stallman
Total pages 67
Total black and white pages 67
Language eng
Subjects 111503 Clinical Pharmacy and Pharmacy Practice
Formatted abstract Aims:
1. To develop a clozapine decision support tool (CDST).
2. To evaluate the effectiveness of the CDST.

Method: A CDST was developed, using current clozapine guidelines and evidence from published literature to support the inclusion of the different components of the tool. The CDST is a compilation of the latest recommendations and information aimed at assisting clinicians in making decisions that are in keeping with current guidelines.
The study to evaluate the effectiveness of the CDST consisted of a pre- and post-interventional audit, with the introduction of CDST in all clinical areas as the intervention, to assess the level of adherence to the clozapine guidelines by clinicians. The study population was made up of all patients at the study site who were on clozapine treatment during the study period. Data collection comprised of a clinical chart plus computer record audit and a prescribing audit that assessed adherence to the monitoring guidelines and prescribing guidelines respectively.

Results: A total of 133 patient records were audited in the study with 67 in the pre-interventional phase and 66 in the post-interventional phase. There was an overall general improvement in clinician adherence to guidelines with statistically significant improvements in monthly physical health monitoring (which can be attributed to the physical health monitoring prompt) and 6 monthly ECG performances.

Conclusion: The results of this study indicate that introduction of the CDST as the intervention was responsible for the observed overall improvement in adherence by clinicians to the clozapine guidelines.
Keyword Clozapine
Schizophrenia

 
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Created: Fri, 24 Aug 2012, 12:20:40 EST by Vanessa Lee King on behalf of School of Pharmacy