Micronutrient, antioxidant, and oxidative stress status in children with severe cerebral palsy

Schoendorfer, Niikee C., Vitetta, Luis, Sharp, Nita, Digeronimo, Michelle, Wilson, Gary, Coombes, Jeff S., Boyd, Roslyn and Davies, Peter S. W. (2013) Micronutrient, antioxidant, and oxidative stress status in children with severe cerebral palsy. Journal of Parenteral and Enteral Nutrition, 37 1: 97-101. doi:10.1177/0148607112447200


Author Schoendorfer, Niikee C.
Vitetta, Luis
Sharp, Nita
Digeronimo, Michelle
Wilson, Gary
Coombes, Jeff S.
Boyd, Roslyn
Davies, Peter S. W.
Total Author Count Override 8
Title Micronutrient, antioxidant, and oxidative stress status in children with severe cerebral palsy
Journal name Journal of Parenteral and Enteral Nutrition   Check publisher's open access policy
ISSN 0148-6071
1941-2444
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1177/0148607112447200
Volume 37
Issue 1
Start page 97
End page 101
Total pages 5
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2013
Language eng
Formatted abstract
Background: Markers indicative of micronutrient and antioxidant status in children with cerebral palsy (CP) were explored due to these children’s well-documented issues with food intake and the limited biochemical literature. Materials and Methods: Children aged 4 to 12 years with marked CP (n = 24) and controls (n = 24) were recruited. The CP group represented orally (O) or enterally fed (E) children. Concentrations of red cell folate (RCF), magnesium, superoxide dismutase (SOD), glutathione reductase, and peroxidase were measured, as well as serum methylmalonic acid and vitamin C. Plasma hemoglobin, C-reactive protein, α-tocopherol, cholesterol, zinc, protein carbonyls, and total antioxidant capacity were also quantified. Results: Data are reported as mean (SD) and z scores where values differ with age. Many similarities existed, but zinc z scores were reduced in O (–1.10 [0.83]) vs controls (–0.54 [0.54]) (P < .05), as well as for glutathione reductase in O (10.15 [1.69]) vs E (12.22 [2.41]) and controls (11.51 [1.67]) (P < .05). RCF was greatly increased in E (1422 [70]) vs O (843 [80]) and controls (820 [43]) (P < .001). SOD was decreased in E (24.3 [1.4]) vs controls (27.0 [2.8]) (P < .05). Conclusion: Considering their vast impact on physiology, micronutrients should be routinely monitored in orally fed children with swallowing disorders and dietary limitations. Excessive intakes, particularly long term in enterally fed children, should also be monitored in view of their potential for competitive inhibition, particularly at high levels.
Keyword Micronutrients
Enteral feeding
Oxidative stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print May 18, 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 18 Aug 2012, 10:59:56 EST by Dr Luis Vitetta on behalf of Medicine - Princess Alexandra Hospital