Coevolution of neuropeptidergic signaling systems: from worm to man

Janssen, Tom, Lindemans, Marleen, Meelkop, Ellen, Temmerman, Liesbet and Schoofs, Liliane (2010) Coevolution of neuropeptidergic signaling systems: from worm to man. Annals of the New York Academy of Sciences, 1200 1-14. doi:10.1111/j.1749-6632.2010.05506.x

Author Janssen, Tom
Lindemans, Marleen
Meelkop, Ellen
Temmerman, Liesbet
Schoofs, Liliane
Title Coevolution of neuropeptidergic signaling systems: from worm to man
Journal name Annals of the New York Academy of Sciences   Check publisher's open access policy
ISSN 0077-8923
ISBN 9781573317986
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1111/j.1749-6632.2010.05506.x
Volume 1200
Start page 1
End page 14
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Despite the general knowledge and repeated predictions of peptide G protein–coupled receptors following the elucidation of the Caenorhabditis elegans genome in 1998, only a few have been deorphanized so far. This was attributed to the apparent lack of coevolution between (neuro)peptides and their cognate receptors. To resolve this issue, we have used an in silico genomic data mining tool to identify the real putative peptide GPCRs in the C. elegans genome and then made a well-considered selection of orphan peptide GPCRs. To maximize our chances of a successful deorphanization, we adopted a combined reverse pharmacology approach. At this moment, we have successfully uncovered four C. elegans neuropeptide signaling systems that support the theory of receptor–ligand coevolution. All four systems are extremely well conserved within nematodes and show a high degree of similarity with their vertebrate and arthropod counterparts. Our data indicate that these four neuropeptide signaling systems have been well conserved during the course of evolution and that they were already well established prior to the divergence of protostomes and deuterostomes.
Keyword Coevolution
C. elegans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Volume 1200 Phylogenetic Aspects of Neuropeptides: From Invertebrates to Humans

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
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