Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis? A cardiac magnetic resonance study

Porto, Italo, Leone, Antonio Maria, De Maria, Giovanni Luigi, Craig, Christian Hamilton, Tritarelli, Alessandra, Camaioni, Claudia, Natale, Luigi, Niccoli, Giampaolo, Biasucci, Luigi M. and Crea, Filippo (2011) Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis? A cardiac magnetic resonance study. Atherosclerosis, 216 2: 355-358. doi:10.1016/j.atherosclerosis.2011.02.014


Author Porto, Italo
Leone, Antonio Maria
De Maria, Giovanni Luigi
Craig, Christian Hamilton
Tritarelli, Alessandra
Camaioni, Claudia
Natale, Luigi
Niccoli, Giampaolo
Biasucci, Luigi M.
Crea, Filippo
Title Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis? A cardiac magnetic resonance study
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2011-06
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2011.02.014
Volume 216
Issue 2
Start page 355
End page 358
Total pages 4
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Background: In ST-elevation myocardial infarction (STEMI) patients, the main stimuli involved in endothelial progenitor cells (EPCs) mobilization are not fully understood. We aimed to assess by cardiac magnetic resonance (CMR) whether the extent of ischemic myocardium (area at risk (AAR)) or of necrotic myocardium (infarct size (IS)) can be correlated to levels of circulating EPCs.
Methods: Peripheral EPCs were measured in fifteen STEMI patients at 24 h after successful primary percutaneous coronary intervention (pPCI). Between two and four days after pPCI all patients underwent CMR assessment of myocardial AAR, IS, myocardial salvage (MS) and microvascular obstruction at late gadolinium enhancement CMR (LG-MVO).
Results: CD34+/KDR+, CD34+/KDR+/CD45dim, CD34+/KDR+/CD45−, EPCs were related to extent of AAR (rho = 0.51, p = 0.05; rho = 0.55, p = 0.03; rho = 0.72, p = 0.002, respectively), while no relationships were detected with IS, MS or LG-MVO.
Conclusions: Our data show that EPCs were strongly correlated to extent of myocardial AAR, thus suggesting that progenitor cells mobilization in STEMI develops in response to myocardial ischemia and not to myocardial necrosis.
Keyword Endothelial progenitor cells
Cardiac magnetic resonance
Area at risk
Microvascular obstruction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
Centre for Advanced Imaging Publications
 
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