Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

Ratheesh, Aparna, Gomez, Guillermo A., Priya, Rashmi, Verma, Suzie, Kovacs, Eva M., Jiang, Kai, Brown, Nicholas H., Akhmanova, Anna, Stehbens, Samantha J. and Yap, Alpha S. (2012) Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nature Cell Biology, 14 8: 818-828. doi:10.1038/ncb2532


Author Ratheesh, Aparna
Gomez, Guillermo A.
Priya, Rashmi
Verma, Suzie
Kovacs, Eva M.
Jiang, Kai
Brown, Nicholas H.
Akhmanova, Anna
Stehbens, Samantha J.
Yap, Alpha S.
Title Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
Journal name Nature Cell Biology   Check publisher's open access policy
ISSN 1465-7392
1476-4679
Publication date 2012-08
Sub-type Article (original research)
DOI 10.1038/ncb2532
Volume 14
Issue 8
Start page 818
End page 828
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract The biological impact of Rho depends critically on the precise subcellular localization of its active, GTP-loaded form. This can potentially be determined by the balance between molecules that promote nucleotide exchange or GTP hydrolysis. However, how these activities may be coordinated is poorly understood. We now report a molecular pathway that achieves exactly this coordination at the epithelial zonula adherens. We identify an extramitotic activity of the centralspindlin complex, better understood as a cytokinetic regulator, which localizes to the interphase zonula adherens by interacting with the cadherin-associated protein, α-catenin. Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA. Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho. Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2012, 15:19:41 EST by Susan Allen on behalf of Institute for Molecular Bioscience