Contact inhibition (of proliferation) redux

McClatchey, Andrea I. and Yap, Alpha S. K. (2012) Contact inhibition (of proliferation) redux. Current Opinion in Cell Biology, 423-424 5: 685-694. doi:10.1016/j.ceb.2012.06.009


Author McClatchey, Andrea I.
Yap, Alpha S. K.
Title Contact inhibition (of proliferation) redux
Journal name Current Opinion in Cell Biology   Check publisher's open access policy
ISSN 0955-0674
1879-0410
Publication date 2012-07-24
Sub-type Article (original research)
DOI 10.1016/j.ceb.2012.06.009
Volume 423-424
Issue 5
Start page 685
End page 694
Total pages 10
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Abstract It has long been appreciated that proliferation of many cells is inhibited by density, a phenomenon that is often attributed to cell-cell contact. The basic properties of this phenomenon were established in the 1960s, along with the observation that such density-dependence was also lost in transformed cells. The mechanistic basis of contact inhibition of proliferation (CIP) has been slower to reveal itself. Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition.
Keyword Proliferation
Cell
Inhibition
Density
Contact inhibition of proliferation (CIP)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 24 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2012, 15:13:05 EST by Susan Allen on behalf of Institute for Molecular Bioscience