Heparin-related nanomaterials

Gu, Z., Rolfe, Barbara E., Thomas, A. C., Campbell, Julie H., Lu, G. Q. Max and Xu, Z. P. (2012). Heparin-related nanomaterials. In David E. Piyathilake and Rhong Liang (Ed.), Heparin, properties, uses and side effects (pp. 159-178) New York, United States: Nova Science.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Gu, Z.
Rolfe, Barbara E.
Thomas, A. C.
Campbell, Julie H.
Lu, G. Q. Max
Xu, Z. P.
Title of chapter Heparin-related nanomaterials
Title of book Heparin, properties, uses and side effects
Place of Publication New York, United States
Publisher Nova Science
Publication Year 2012
Sub-type Research book chapter (original research)
ISBN 9781621004318
Editor David E. Piyathilake
Rhong Liang
Chapter number 7
Start page 159
End page 178
Total pages 20
Total chapters 12
Collection year 2013
Language eng
Abstract/Summary This chapter reviews heparin as a component of drug delivery system and as a drug to be delivered by nano-carriers for its therapeutic improvement. Heparin is a biocompatible polysaccharide administrated mainly as an anti-coagulant. Due to its outstanding biological and pharmacological activities, heparin has been used to produce delivery systems for cancer therapy, tissue and bone engineering. Heparin has been used to surface-functionalize a variety of nanoparticles, including liposomes, polymers, metal nanoparticles and carbon nanotubes. The virtues of heparin coating include avoiding phagocyte elimination, facilitating internalization by tumor cells and improving blood compatibility. Like many other drugs, heparin has therapeutic limitations, such as short half-life, systemic side-effects, low oral absorption and poor patient compliance, which can be overcome by using nano-carriers. These nano-carriers include liposomes, polymers and inorganic layered double hydroxides. Conjugation of heparin to biofunctional molecules, such as deoxycholic acid and antibody, has also been studied for efficient delivery of heparin. Finally, this chapter has also provided the perspectives for future development of heparin-related nanomaterials.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 14 Aug 2012, 11:50:01 EST by Anthony Yeates on behalf of Aust Institute for Bioengineering & Nanotechnology