Towards an integrated venomics approach for accelerated conopeptide discovery

Jutty Rajan, Prashanth, Lewis, Richard J. and Dutertre, Sebastien (2012) Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon, 60 4: 470-477. doi:10.1016/j.toxicon.2012.04.340

Author Jutty Rajan, Prashanth
Lewis, Richard J.
Dutertre, Sebastien
Title Towards an integrated venomics approach for accelerated conopeptide discovery
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2012-09-15
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2012.04.340
Volume 60
Issue 4
Start page 470
End page 477
Total pages 8
Editor Juan Calvete
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Abstract Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways. As a result, these venoms are a source of valuable pharmacological and therapeutic agents. The traditional approach towards conopeptide discovery relied on activity-guided fractionation, which is time consuming and resource-intensive. In this review, we discuss the advances in the fields of transcriptomics, proteomics and bioinformatics that now allow researchers to integrate these three platforms towards a more efficient discovery strategy. In this review, we also highlight the challenges associated with the wealth of data generated with this integrated approach and briefly discuss the impact these methods could have on the field of toxinology.
Keyword Venomics
Next generation sequencing
Mass spectrometry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special issue: Advancing in Basic and Translational Venomics

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 08 Aug 2012, 10:44:01 EST by Susan Allen on behalf of Institute for Molecular Bioscience