Characterization and evolution of 5′ and 3′ untranslated regions in eukaryotes

Liu, Honglei, Yin, Jiaming, Xiao, Meili, Gao, Caihua, Mason, Annaliese S., Zhao, Zunkang, Liu, Yingchun, Li, Jiana and Fu, Donghui (2012) Characterization and evolution of 5′ and 3′ untranslated regions in eukaryotes. Gene, 507 2: 106-111. doi:10.1016/j.gene.2012.07.034


Author Liu, Honglei
Yin, Jiaming
Xiao, Meili
Gao, Caihua
Mason, Annaliese S.
Zhao, Zunkang
Liu, Yingchun
Li, Jiana
Fu, Donghui
Title Characterization and evolution of 5′ and 3′ untranslated regions in eukaryotes
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
1879-0038
Publication date 2012-10-10
Sub-type Article (original research)
DOI 10.1016/j.gene.2012.07.034
Volume 507
Issue 2
Start page 106
End page 111
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Abstract Untranslated regions (UTRs) in eukaryotes play a significant role in the regulation of translation and mRNA half-life, as well as interacting with specific RNA-binding proteins. However, UTRs receive less attention than more crucial elements such as genes, and the basic structural and evolutionary characteristics of UTRs of different species, and the relationship between these UTRs and the genome size and species gene number is not well understood. To address these questions, we performed a comparative analysis of 5′ and 3′ untranslated regions of different species by analyzing the basic characteristics of 244,976 UTRs from three eukaryote kingdoms (Plantae, Fungi, and Protista). The results showed that the UTR lengths and SSR frequencies in UTRs increased significantly with increasing species gene number while the length and G + C content in 5′ UTRs and different types of repetitive sequences in 3′ UTRs increased with the increase of genome size. We also found that the sequence length of 5′ UTRs was significantly positively correlated with the presence of transposons and SSRs while the sequence length of 3′ UTRs was significantly positively correlated with the presence of tandem repeat sequences. These results suggested that evolution of species complexity from lower organisms to higher organisms is accompanied by an increase in the regulatory complexity of UTRs, mediated by increasing UTR length, increasing G + C content of 5′ UTRs, and insertion and expansion of repetitive sequences.
Keyword Repetitive sequences
Genome size
Species gene number
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 27 July 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Centre for Integrative Legume Research Publications
School of Agriculture and Food Sciences
Official 2013 Collection
 
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Created: Tue, 07 Aug 2012, 21:47:33 EST by Annaliese Mason on behalf of School of Agriculture and Food Sciences