Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

Eyles, Darryl, Burne, Thomas H. J. and McGrath, John J. (2013) Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34 1: 47-64.


Author Eyles, Darryl
Burne, Thomas H. J.
McGrath, John J.
Title Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
Journal name Frontiers in Neuroendocrinology   Check publisher's open access policy
ISSN 0091-3022
1095-6808
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.yfrne.2012.07.001
Volume 34
Issue 1
Start page 47
End page 64
Total pages 18
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2013
Language eng
Abstract Increasingly vitamin D deficiency is being associated with a number of psychiatric conditions. In particular for disorders with a developmental basis, such as autistic spectrum disorder and schizophrenia the neurobiological plausibility of this association is strengthened by the preclinical data indicating vitamin D deficiency in early life affects neuronal differentiation, axonal connectivity, dopamine ontogeny and brain structure and function. More recently epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer’s disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link. In this review we have attempted to integrate this clinical epidemiology with potential vitamin D-mediated basic mechanisms. Throughout the review we have highlighted areas where we think future research should focus.
Keyword Vitamin D
Brain
Development
Degeneration
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 11 July 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
 
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Created: Mon, 06 Aug 2012, 15:28:40 EST by Debra McMurtrie on behalf of Queensland Brain Institute