Complement activation in the injured central nervous system: Another dual-edged sword?

Brennan, Faith H., Anderson, Aileen J., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012) Complement activation in the injured central nervous system: Another dual-edged sword?. Journal of Neuroinflammation, 9 1: . doi:10.1186/1742-2094-9-137


Author Brennan, Faith H.
Anderson, Aileen J.
Taylor, Stephen M.
Woodruff, Trent M.
Ruitenberg, Marc J.
Title Complement activation in the injured central nervous system: Another dual-edged sword?
Formatted title
Complement activation in the injured central nervous system: Another dual-edged sword?
Journal name Journal of Neuroinflammation   Check publisher's open access policy
ISSN 1742-2094
1742-2094
Publication date 2012-06-21
Sub-type Article (original research)
DOI 10.1186/1742-2094-9-137
Open Access Status DOI
Volume 9
Issue 1
Total pages 28
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Abstract The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators support various aspects of both normal central nervous system (CNS) function and pathology has led to a renaissance of complement research in neuroscience. Various studies have revealed particularly novel findings on the wide-ranging involvement of complement in neural development, synapse elimination and maturation of neural networks, as well as the progression of pathology in a range of chronic neurodegenerative disorders, and more recently, neurotraumatic events, where rapid disruption of neuronal homeostasis potently triggers complement activation. The purpose of this review is to summarise recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article no. 137

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 06 Aug 2012, 12:59:48 EST by Debra McMurtrie on behalf of Queensland Brain Institute