Renal and small-intestinal sodium-dependent symporters of phosphate and sulfate

Murer, Heini, Markovich, Daniel and Biber, Juerg (1994) Renal and small-intestinal sodium-dependent symporters of phosphate and sulfate. Journal of Experimental Biology, 196 167-181.

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Author Murer, Heini
Markovich, Daniel
Biber, Juerg
Title Renal and small-intestinal sodium-dependent symporters of phosphate and sulfate
Journal name Journal of Experimental Biology   Check publisher's open access policy
ISSN 0022-0949
1477-9145
Publication date 1994-11
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 196
Start page 167
End page 181
Total pages 15
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Formatted abstract
Homeostasis of inorganic phosphate (Pi) and sulphate (Si) is largely achieved by absorption in the mammalian small intestine and by reabsorption in the proximal tubule of the kidney. Under normal physiological conditions, the kidney appears to play the major role in maintaining the extracellular concentration of these anions. In both epithelia, reabsorption of Pi and to some extent also of Si underlie a variety of regulatory acute and chronic control mechanisms. Acute regulatory mechanisms are predominantly found in renal Pi reabsorption, whereas chronic regulation of transepithelial Pi transport is observed in both tissues. Also, in both epithelia, apically located sodium-dependent transport systems (Na+/Pi and Na+/Si symport) represent major targets for known regulatory factors. By expression cloning using oocytes of Xenopus laevis, renal and small intestinal Na+- dependent phosphate and sulphate transport systems have been identified. Evidence has been obtained that cloned Na+/Pi and Na+/Si symporters are localized in the apical membrane of proximal tubular or small intestinal epithelial cells respectively. Furthermore, recent results indicate that one of the cloned Na+/Pi symporters is involved in the physiological and pathophysiological regulation of proximal tubular Preabsorption.
Keyword Na+ phosphate symport
Na+ sulfate symport
Brush-border membrane
Proximal tubule
Small intestine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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