Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer

Cartmill, Bena, Cornwell, Petrea, Ward, Elizabeth, Davidson, Wendy, Nund, Rebecca, Bettington, Catherine, Rahbari, Reza Masoud, Poulsen, Michael and Porceddu, Sandro (2013) Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer. Head and Neck, 35 8: 1211-1219.

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Author Cartmill, Bena
Cornwell, Petrea
Ward, Elizabeth
Davidson, Wendy
Nund, Rebecca
Bettington, Catherine
Rahbari, Reza Masoud
Poulsen, Michael
Porceddu, Sandro
Title Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2013-08
Year available 2012
Sub-type Article (original research)
DOI 10.1002/hed.23040
Volume 35
Issue 8
Start page 1211
End page 1219
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract Background
Research has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment.

Methods

Dose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose–volume histograms for 12 patients with T1–T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment.

Results

In all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months.

Conclusion
The relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes.
Keyword Radiation dosimetry
Dose-volume histogram
Oropharyngeal cancer
Swallowing
Nutrition
Function outcomes
Open Access Mandate Compliance No - Does Not Comply
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 22 June 2012 This research was presented at the Tri-Society Oncology Meeting in Singapore, September 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
 
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Created: Fri, 03 Aug 2012, 10:26:34 EST by Matthew Lamb on behalf of School of Medicine