Discovery and applications of disulfide-rich cyclic peptides

Cemazar, M., Kwon, S., Mahatmanto, T., Ravipati, A. S. and Craik, David J. (2012) Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry, 12 14: 1534-1545. doi:10.2174/156802612802652484

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Cemazar, M.
Kwon, S.
Mahatmanto, T.
Ravipati, A. S.
Craik, David J.
Title Discovery and applications of disulfide-rich cyclic peptides
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
1873-4294
Publication date 2012-07-17
Sub-type Article (original research)
DOI 10.2174/156802612802652484
Volume 12
Issue 14
Start page 1534
End page 1545
Total pages 12
Place of publication Bussum, Netherlands
Publisher Bentham Science
Collection year 2013
Language eng
Abstract Cyclic peptides typically have much higher stability and improved biopharmaceutical properties over their linear counterparts. Our work focuses on the discovery of naturally occurring disulfide-rich cyclic peptides and their applications in drug design. These peptides provide a design basis for re-engineering natural acyclic peptides to improve their biopharmaceutical properties by chemically linking their termini. Here we describe examples of the discovery of the cyclotide family of peptides, their chemical re-engineering to introduce desired pharmaceutical activities, studies of their biopharmaceutical properties and applications of cyclization technologies to naturally occurring toxins, including conotoxins and scorpion toxins. In the case of the conotoxin Vc1.1, we produced an orally active peptide with potential for the treatment of neuropathic pain by cyclising the native peptide.In the case of the scorpion toxin chlorotoxin, a cyclised derivative had improved biopharmaceutical properties as a tumour imaging agent over the naturally occurring linear chlorotoxin. Ongoing chemical and structural studies of these classes of disulfide-rich peptides promise to increase their value for use in dissecting biological processes in plants and mammals while also providing leads to new classes of biopharmaceuticals.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
ERA White List Items
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 01 Aug 2012, 15:16:02 EST by Susan Allen on behalf of Institute for Molecular Bioscience