Antibiotic therapy of pneumonia in critical care

Dhanani, Jayesg, Roberts, Jason A. and Lipman, Jeffrey (2012) Antibiotic therapy of pneumonia in critical care. Current Respiratory Medicine Reviews, 8 3: 228-238. doi:10.2174/157339812800493232

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Dhanani, Jayesg
Roberts, Jason A.
Lipman, Jeffrey
Title Antibiotic therapy of pneumonia in critical care
Journal name Current Respiratory Medicine Reviews   Check publisher's open access policy
ISSN 1573-398X
Publication date 2012-06
Sub-type Article (original research)
DOI 10.2174/157339812800493232
Volume 8
Issue 3
Start page 228
End page 238
Total pages 11
Place of publication Oak Park, IL, U.S.A.
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract The effective treatment of pneumonia in a critical care setting involves optimal administration of antibiotics. Various micro-organisms are responsible for causing pneumonia. As the pathogen may not always be evident, empiric broad spectrum antibiotic regimens are often used. There are various resources available to guide antibiotic therapy but unfortunately these have not been validated in critically ill patients. Of increasing concern, multidrug resistant bacteria are becoming more prevalent in the critical care units causing a paradigm shift for antibiotic therapy. In the context of a diminishing pipeline of antibiotic development, optimal use of available antibiotics is essential. Alternative modes of administration such as aerosolisation should be considered especially in nosocomial, multidrug resistant organisms. Further to this, de-escalation of antibiotics and antibiotic cycling are some of the strategies that can be utilised to reduce the emergence of multidrug resistant bacteria. Improvement of clinical outcomes for pneumonia in critical care may also be achieved through use of therapeutic drug monitoring and combination therapy. We advocate that the rational development of local antibiograms for critical care units to better guide the empiric antibiotic therapy in these patients.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 31 Jul 2012, 02:05:04 EST by Matthew Lamb on behalf of School of Medicine