Advances in peptide-based Human papillomavirus therapeutic vaccines

Liu, Tzu-Yu, Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2012) Advances in peptide-based Human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry, 12 14: 1581-1592. doi:10.2174/156802612802652402

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Author Liu, Tzu-Yu
Hussein, Waleed M.
Toth, Istvan
Skwarczynski, Mariusz
Title Advances in peptide-based Human papillomavirus therapeutic vaccines
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
Publication date 2012-07-17
Sub-type Article (original research)
DOI 10.2174/156802612802652402
Open Access Status File (Author Post-print)
Volume 12
Issue 14
Start page 1581
End page 1592
Total pages 12
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract Cervical cancer is the second leading cause of cancer in women worldwide. Human papillomavirus (HPV) is responsible for all cases of cervical cancer. Commercial prophylactic HPV vaccines are now available, but unfortunately these vaccines have no therapeutic effect against established HPV infections. In order to accelerate the control of cervical cancer and treat established HPV infections, it is necessary to develop therapeutic vaccines to eradicate HPV by generating cell-mediated immunity against HPV infected cells. Two HPV-encoded early proteins, the E6 and E7 oncoproteins, are the preferred targets because they are consistently expressed in virtually all cervical cancer cells and are necessary for the induction and maintenance of HPV-associated disease. A variety of vaccine strategies have been employed targeting immune responses to these proteins. Peptide-based vaccines are a promising strategy for the development of therapeutic HPV vaccines because of their safety, stability, and ease of production. This review summarizes the prospects of peptidebased vaccines for the treatment of established HPV infections. We address the challenges that scientists currently face for developing peptide-based vaccines and explore feasible strategies for improving the potency of the induced immune response with the aim of treating established HPV infections.
Keyword Peptide subunit vaccine
Anticancer vaccine
Therapeutic vaccine
Cervical cancer
Human papillomavirus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Mon, 30 Jul 2012, 09:40:09 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences