Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers

Gunness, Purnima, Flanagan, Bernadine M., Shelat, Kinnari, Gilbert, Robert G. and Gidley, Michael J. (2012) Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers. Food Chemistry, 134 4: 2007-2013. doi:10.1016/j.foodchem.2012.03.131


Author Gunness, Purnima
Flanagan, Bernadine M.
Shelat, Kinnari
Gilbert, Robert G.
Gidley, Michael J.
Title Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers
Journal name Food Chemistry   Check publisher's open access policy
ISSN 0308-8146
1873-7072
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1016/j.foodchem.2012.03.131
Volume 134
Issue 4
Start page 2007
End page 2013
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Abstract The kinetics of passage of a model bile salt and complete porcine bile across a dialysis membrane, in the presence and absence of two cereal-derived soluble dietary fibre polysaccharides, were studied as a model for passage across the unstirred water layer that lines the small intestine. A first-order kinetic analysis allowed rate coefficients to be derived which quantified the effectiveness of barley mixed linkage β-glucan and wheat arabinoxylan in retarding the transport of bile. For both, a model bile salt and complete porcine bile, rate coefficients decreased with both concentration and viscosity. A combination of viscosity and molecular interaction effects is suggested to control the effect of the two polysaccharides on the transport of bile.
Keyword (1,3:1,4)-b-D-glucan
Arabinoxylan
Bile salt
Viscosity
Dialysis kinetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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