Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans

Farrell, Michael J., Cole, Leonie J., Chiapoco, David, Egan, Gary F. and Mazzone, Stuart B. (2012) Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans. NeuroImage, 61 4: 1324-1335. doi:10.1016/j.neuroimage.2012.03.030

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Author Farrell, Michael J.
Cole, Leonie J.
Chiapoco, David
Egan, Gary F.
Mazzone, Stuart B.
Title Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2012-07-01
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2012.03.030
Open Access Status File (Author Post-print)
Volume 61
Issue 4
Start page 1324
End page 1335
Total pages 12
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2013
Language eng
Abstract The perception of airways irritation is represented in a distributed brain network. However, the functional roles of sub-regions of this network are yet to be determined. The aim of this study was to measure brain activation in healthy participants as they inhaled two doses of capsaicin to identify dose-dependent and dose-independent responses. Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) measures of brain responses during inhalation of saline, and a low and high dose of capsaicin were made from 16 healthy participants. Subjective ratings of the urge-to-cough were also made during capsaicin challenges. The majority of brain regions that were activated during capsaicin inhalation, including insula and mid cingulate cortex, showed graduated responses to the two doses of capsaicin. Prefrontal and parietal regions had dose-independent activation, whereas premotor regions and the cerebellum activated exclusively at the high dose of capsaicin. Activation in the somatosensory and mid-cingulate cortices correlated with ratings of urge-to-cough. In the brainstem, capsaicin produced dose-dependent activations in respiratory-related regions of the dorsal pons and lateral medulla. These data show dissociable response patterns to capsaicin inhalation that may represent different regional processes involved in monitoring and assessing stimulus intensity, determining the spatial localization of the stimulus and suppressing motor responses.
Keyword Cough
Respiratory sensation
Blood oxygen level dependent
Cortex
Functional magnetic resonance imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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