Automated criterion-based analysis for Cole parameters assessment from cerebral neonatal electrical bioimpedance spectroscopy measurements

Seoane, F., Ward, L. C., Lindecrantz, Kaj and Lingwood, B. E. (2012) Automated criterion-based analysis for Cole parameters assessment from cerebral neonatal electrical bioimpedance spectroscopy measurements. Physiological Measurement, 33 8: 1363-1377. doi:10.1088/0967-3334/33/8/1363


Author Seoane, F.
Ward, L. C.
Lindecrantz, Kaj
Lingwood, B. E.
Title Automated criterion-based analysis for Cole parameters assessment from cerebral neonatal electrical bioimpedance spectroscopy measurements
Journal name Physiological Measurement   Check publisher's open access policy
ISSN 0967-3334
1361-6579
Publication date 2012-08-01
Sub-type Article (original research)
DOI 10.1088/0967-3334/33/8/1363
Volume 33
Issue 8
Start page 1363
End page 1377
Total pages 15
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Collection year 2013
Language eng
Formatted abstract
Hypothermia has been proven as an effective rescue therapy for infants with moderate or severe neonatal hypoxic ischemic encephalopathy. Hypoxia-ischemia alters the electrical impedance characteristics of the brain in neonates; therefore, spectroscopic analysis of the cerebral bioimpedance of the neonate may be useful for the detection of candidate neonates eligible for hypothermia treatment. Currently, in addition to the lack of reference bioimpedance data obtained from healthy neonates, there is no standardized approach established for bioimpedance spectroscopy data analysis. In this work, cerebral bioimpedance measurements (12 h postpartum) in a cross-section of 84 term and near-term healthy neonates were performed at the bedside in the post-natal ward. To characterize the impedance spectra, Cole parameters (R0, R, fC and α) were extracted from the obtained measurements using an analysis process based on a best measurement and highest likelihood selection process. The results obtained in this study complement previously reported work and provide a standardized criterion-based method for data analysis. The availability of electrical bioimpedance spectroscopy reference data and the automatic criterion-based analysis method might support the development of a non-invasive method for prompt selection of neonates eligible for cerebral hypothermic rescue therapy.
Keyword Electrical bioimpedance spectroscopy
Perinatal asphyxia
Cole function
Cerebral monitoring
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 27 Jul 2012, 19:08:21 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences