Lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2012) Lipoamino acids as major components of absorption promoters in drug delivery. Current Topics in Medicinal Chemistry, 12 14: 1562-1580. doi:10.2174/156802612802652448

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Author Ziora, Zyta M.
Blaskovich, Mark A.
Toth, Istvan
Cooper, Matthew A.
Title Lipoamino acids as major components of absorption promoters in drug delivery
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
1873-4294
Publication date 2012-07-17
Sub-type Article (original research)
DOI 10.2174/156802612802652448
Volume 12
Issue 14
Start page 1562
End page 1580
Total pages 19
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract Many biologically active compounds are unsuitable for development as drugs due to their poor bioavailability. For hydrophilic compounds, modifications to increase lipophilicity can increase passive diffusion or increase uptake into the lymphatic system. Alternatively, improved bioavailability of hydrophilic drug candidates may be achieved by formulation with absorption promoters such as surfactants, penetration enhancers, or ion pairing agents. This approach to enhancing bioavailability also has the potential to widen the range of compound categories that can be used as chemical probes to study biological systems in cells and in vivo where membrane permeability would otherwise be a significant limitation. Lipidic amino acids, which combine the structural properties of lipids with those of α-amino acids, represent a relatively unexplored class of agents that can improve drug adsorption. This review discusses the potential of absorption promoters possessing lipoamino acids for improving drug bioavailability.
Keyword Absorption promoter
Dendrimers
Drug bioavailability
Drug delivery
Ion pairing agents
Lipoamino acids
Penetration enhancers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes E-Pub Ahead of Schedule - 17 July 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Fri, 27 Jul 2012, 08:53:58 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences