Intervening to improve psychological outcomes for men with prostate cancer

Chambers, Suzanne K., Ferguson, Megan, Gardiner, R. A., Aitken, Joanne and Occhipinti, Stefano (2013) Intervening to improve psychological outcomes for men with prostate cancer. Psycho-Oncology, 22 5: 1025-1034. doi:10.1002/pon.3095

Author Chambers, Suzanne K.
Ferguson, Megan
Gardiner, R. A.
Aitken, Joanne
Occhipinti, Stefano
Title Intervening to improve psychological outcomes for men with prostate cancer
Journal name Psycho-Oncology   Check publisher's open access policy
ISSN 1057-9249
Publication date 2013-05
Year available 2012
Sub-type Article (original research)
DOI 10.1002/pon.3095
Open Access Status
Volume 22
Issue 5
Start page 1025
End page 1034
Total pages 10
Place of publication Bognor Regis, West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
Background: Prostate cancer is the most common cancer in men in the Western world with well-described negative effects from treatments. However, outcomes are highly heterogeneous. A Phase 3 trial of a psycho-educational intervention was undertaken, aiming to reduce cancer-specific and decision-related distress and improve quality of life for men newly diagnosed with localised prostate cancer.

Methods: Seven hundred forty (81.7%) men were recruited after diagnosis and before treatment and randomised to a tele-based nurse-delivered five-session psycho-educational intervention (N = 372) or usual care (N = 368). Participants were assessed before treatment and 2, 6, 12 and 24 months post-treatment. Outcome measures included cancer-specific and decision-related distress, cognitive judgmental adjustment, subjective well-being, and domain-specific and health-related quality of life. Social support was assessed as a potential moderator.

Results: No unconditioned effects were found. Classification analyses on pre-randomisation measures distinguished three subgroups: younger, higher education and income men (N = 290); younger, lower education and income men (N = 106); and older men (N = 344). Younger, higher education and income men showed positive intervention effects for cancer-specific distress ( p = 0.008) and mental health ( p = 0.042). By contrast, for younger, lower education men, participation in the intervention was associated with decreases in cognitive judgmental adjustment over time ( p = 0.006).

Conclusions: Response to intervention and adjustment over time varied according to previous sexual functioning, age, educational level and income. How to best intervene with younger, low education, low income men with prostate cancer is a critical future research question.
Keyword Prostate cancer
Psycho-educational intervention
Psychological adjustment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 2 MAY 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 26 Jul 2012, 12:54:10 EST by Jessica Eldridge on behalf of UQ Centre for Clinical Research