Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins

Hibar, Derrek P., Jahanshad, Neda, Stein, Jason L., Kohannim, Omid, Toga, Arthur W., Medland, Sarah E., Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J. and Thompson, Paul M. (2012) Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins. Twin Research and Human Genetics, 15 3: 286-295.

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Author Hibar, Derrek P.
Jahanshad, Neda
Stein, Jason L.
Kohannim, Omid
Toga, Arthur W.
Medland, Sarah E.
Hansell, Narelle K.
McMahon, Katie L.
de Zubicaray, Greig I.
Montgomery, Grant W.
Martin, Nicholas G.
Wright, Margaret J.
Thompson, Paul M.
Title Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins
Formatted title Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins
Journal name Twin Research and Human Genetics  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012-06
Sub-type Article
DOI 10.1017/thg.2012.15
Volume number 15
Issue number 3
ISSN 1832-4274; 1839-2628
Start page 286
End page 295
Total pages 10
Editor Greig de Zubicaray
Dirk Smit
Jason Stein
Dennis van 't Ent
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2013
Language eng
Formatted abstract The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.
Keyword GAB2
Imaging genetics
Tensor-based morphometry
Alzheimer's disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue 03 (Genetics of brain structure and function)

 
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Created: Thu, 26 Jul 2012, 10:59:42 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging