Duplication and inversion history of a tandemly repeated genes family

Lajoie, Mathieu, Bertrand, Denis, El-Mabrouk, Nadia and Gascuel, Olivier (2007) Duplication and inversion history of a tandemly repeated genes family. Journal of Computational Biology, 14 4: 462-478. doi:10.1089/cmb.2007.A007

Author Lajoie, Mathieu
Bertrand, Denis
El-Mabrouk, Nadia
Gascuel, Olivier
Title Duplication and inversion history of a tandemly repeated genes family
Journal name Journal of Computational Biology   Check publisher's open access policy
ISSN 1066-5277
Publication date 2007-05
Sub-type Article (original research)
DOI 10.1089/cmb.2007.A007
Volume 14
Issue 4
Start page 462
End page 478
Total pages 17
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Language eng
Formatted abstract
Given a phylogenetic tree for a family of tandemly repeated genes and their signed order on the chromosome, we aim to find the minimum number of inversions compatible with an evolutionary history of this family. This is the first attempt to account for inversions in an evolutionary model of tandemly repeated genes. We present a branch-and-bound algorithm that finds the exact solution, and a polynomial-time heuristic based on the breakpoint distance. We show, on simulated data, that those algorithms can be used to improve phylogenetic inference of tandemly repeated gene families. An application on a published phylogeny of KRAB zinc finger genes is presented.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
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Created: Wed, 25 Jul 2012, 11:20:34 EST by Susan Allen on behalf of Institute for Molecular Bioscience