Encapsulation and controlled release of biomolecules from silica microparticles

Finnie, K. S., Jacques, D. A., McGann, M. J., Blackford, M. G. and Barbe, C. J. (2006) Encapsulation and controlled release of biomolecules from silica microparticles. Journal of Materials Chemistry, 16 46: 4494-4498. doi:10.1039/b611840b

Author Finnie, K. S.
Jacques, D. A.
McGann, M. J.
Blackford, M. G.
Barbe, C. J.
Title Encapsulation and controlled release of biomolecules from silica microparticles
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
Publication date 2006
Sub-type Article (original research)
DOI 10.1039/b611840b
Open Access Status Not Open Access
Volume 16
Issue 46
Start page 4494
End page 4498
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract Biomolecules have been encapsulated in silica microparticles for controlled release applications, by destabilisation of aqueous silica precursors in the water droplets of a water-in-oil emulsion. The use of colloidal solutions (colloids typically in the size range 6–20 nm) as silica precursors avoids the detrimental effect of alcohol in the reactant solution. Thus, subtilisin A has been encapsulated with little to no loss in enzymatic activity. The particles are mesoporous, with a well-defined pore-size in the order of the size of most proteins, enabling the molecules to diffuse out of the solid. The release rate can be controlled by adjusting the pore-size of the silica particles.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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Created: Wed, 25 Jul 2012, 10:59:09 EST by Susan Allen on behalf of Institute for Molecular Bioscience