Magnetically loaded drug molecules and their stability in smart bionanocomposites

Chaudhary, Deeptangshu, Haroosh, Hazim, John, Joseph, Lim, Median, Guagliardo, Paul, Foreman, Marnie and Yusa, Shin-ichi (2011). Magnetically loaded drug molecules and their stability in smart bionanocomposites. In: Chemeca 2011 Proceedings. CHEMECA 2011 Engineering a better world, Sydney, Australia, (). 18 - 21 September 2011.

Author Chaudhary, Deeptangshu
Haroosh, Hazim
John, Joseph
Lim, Median
Guagliardo, Paul
Foreman, Marnie
Yusa, Shin-ichi
Title of paper Magnetically loaded drug molecules and their stability in smart bionanocomposites
Conference name CHEMECA 2011 Engineering a better world
Conference location Sydney, Australia
Conference dates 18 - 21 September 2011
Proceedings title Chemeca 2011 Proceedings
Publication Year 2011
Sub-type Published abstract
Language eng
Abstract/Summary We present some interesting results on drug loading behaviour of bionanocomposites made from poly (ethylene oxide)-chitosan based biopolymer matrix with various paramagnetic and superparamagnetic nanoparticles. A facile route for developing these bionanocomposites is discussed, which includes the synthesis of superparamagnetic nanoparticles in poly (ethylene oxide) and in chitosan at different loading and fabrication of nanofibers-containing polymer fibers/beads. The model drug, Ibuprofen, had a nominal drug loading of 50mg/g of carrier. However, when the beads were subjected to external magnetic field, the drug loading behaviour was altered and the nominal drug loading was found to increase by 12-22% of carrier. Drug loading behaviour under low temperatures (below the glass transition temperature of the matrix) and under external magnetic field was also carrier out. Further, molecular pore size distribution of the bionanocomposites was investigated using Positron Annhilation Lifetime Spectroscopy and Doppler broadening spectrum to determine if the variation in external magnetic field influences the pore sizes and thus the drug loading behaviour. The release kinetics of both magnetically induced drug loaded and non-magnetically induced drug loaded carrier showed linear cumulative response against log(time). Electron microscopy characterisation reveals an interesting surface of the bionanocomposite carrier; a highly convoluted surface topography highlighting a high surface area to volume ratio.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: Julius Kruttschnitt Mineral Research Centre Publications
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Created: Tue, 24 Jul 2012, 14:21:55 EST by Karen Holtham on behalf of Julius Kruttschnitt Mineral Research Centre