Gastrointestinal pathology in celiac disease: A case series of 150 consecutive newly diagnosed patients

Brown, Ian S., Smith, Jason and Rosty, Christophe (2012) Gastrointestinal pathology in celiac disease: A case series of 150 consecutive newly diagnosed patients. American Journal of Clinical Pathology, 138 1: 42-49.


Author Brown, Ian S.
Smith, Jason
Rosty, Christophe
Title Gastrointestinal pathology in celiac disease: A case series of 150 consecutive newly diagnosed patients
Journal name American Journal of Clinical Pathology   Check publisher's open access policy
ISSN 0002-9173
1943-7722
Publication date 2012-07
Sub-type Article (original research)
DOI 10.1309/AJCPE89ZPVJTSPWL
Volume 138
Issue 1
Start page 42
End page 49
Total pages 8
Place of publication Birmingham, AL, United States
Publisher American Society for Clinical Pathology
Collection year 2013
Language eng
Abstract The main histologic feature of celiac disease is increased intraepithelial lymphocytes (IELs) with or without villous atrophy of the duodenal mucosa. The aim of this study was to document a broad range of additional morphologic changes in intestinal mucosa biopsy specimens from patients with celiac disease. Our cohort comprised 150 patients with positive tissue transglutaminase serologic findings; 7 were at Corazza stage A1, 58 at stage B1, and 85 at stage B2. IEL counts per 100 epithelial cells ranged from 34 to 156 (mean, 88.6); a significant neutrophilic infiltrate was present in 85 cases (56.7%); eosinophil count ranged from 3 to 50 per high-power field (mean, 14.6). Additional findings included morphologic changes in enterocytes in 68.7%, subepithelial collagen thickening in 45.3%, and associated lymphocytic gastritis in 30.4% of patients. We demonstrated that these underrecognized features, which can be misleading, are not uncommon in celiac disease and were positively associated with more advanced stages of the disease (P < .0001).
Keyword Celiac disease
Gluten sensitivity
Villous atrophy
Mucosal eosinophilia
Collagen band
Lymphocytic gastritis
Lymphocytic colitis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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