Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin

Serisier, D. J. (2012) Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin. Drugs of Today, 48 5: 339-351.

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Author Serisier, D. J.
Title Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin
Journal name Drugs of Today  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012-05
Sub-type Article
DOI 10.1358/dot.2012.48.5.1789474
Volume number 48
Issue number 5
ISSN 1699-3993; 1699-4019
Start page 339
End page 351
Total pages 13
Place of publication Barcelona, Spain
Publisher Prous Science
Collection year 2013
Language eng
Abstract The administration of antibiotics by the inhaled route offers an appealing and logical approach to treating infectious respiratory conditions. Studies in the cystic fibrosis (CF) population have established the efficacy of this therapeutic concept and inhaled antibiotic therapy is now one of the pillars of management in CF. There are now a number of new inhaled antibiotic formulations that have shown impressive preliminary evidence for efficacy in CF and are commencing phase III efficacy studies. Translation of this paradigm into the non-CF bronchiectasis population has proven difficult thus far, apparently due to problems with tolerability of inhaled formulations. Inhaled versions of ciprofloxacin have shown good tolerability and microbiological efficacy in preliminary studies, suggesting that effective inhaled antibiotics are finally on the horizon for this previously neglected patient population. The increased use of long-term inhaled antibiotics for a wider range of non-CF indications presents risks to the broader community of greater antimicrobial resistance development that must be carefully weighed against any demonstrated benefits.
Keyword Ciprofloxacin
Ard-1100
Quinolone
Ard-3150
Respiratory disorders
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
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