Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin

Serisier, D. J. (2012) Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin. Drugs of Today, 48 5: 339-351. doi:10.1358/dot.2012.48.5.1789474

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Author Serisier, D. J.
Title Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin
Journal name Drugs of Today   Check publisher's open access policy
ISSN 1699-3993
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1358/dot.2012.48.5.1789474
Volume 48
Issue 5
Start page 339
End page 351
Total pages 13
Place of publication Barcelona, Spain
Publisher Prous Science
Collection year 2013
Language eng
Abstract The administration of antibiotics by the inhaled route offers an appealing and logical approach to treating infectious respiratory conditions. Studies in the cystic fibrosis (CF) population have established the efficacy of this therapeutic concept and inhaled antibiotic therapy is now one of the pillars of management in CF. There are now a number of new inhaled antibiotic formulations that have shown impressive preliminary evidence for efficacy in CF and are commencing phase III efficacy studies. Translation of this paradigm into the non-CF bronchiectasis population has proven difficult thus far, apparently due to problems with tolerability of inhaled formulations. Inhaled versions of ciprofloxacin have shown good tolerability and microbiological efficacy in preliminary studies, suggesting that effective inhaled antibiotics are finally on the horizon for this previously neglected patient population. The increased use of long-term inhaled antibiotics for a wider range of non-CF indications presents risks to the broader community of greater antimicrobial resistance development that must be carefully weighed against any demonstrated benefits.
Keyword Ciprofloxacin
Respiratory disorders
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Mon, 23 Jul 2012, 17:12:25 EST by System User on behalf of School of Medicine