Host-defense activities of cyclotides

Craik, David J. (2012) Host-defense activities of cyclotides. Toxins, 4 2: 139-156. doi:10.3390/toxins4020139

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Craik, David J.
Title Host-defense activities of cyclotides
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2012-02-15
Sub-type Article (original research)
DOI 10.3390/toxins4020139
Open Access Status DOI
Volume 4
Issue 2
Start page 139
End page 156
Total pages 18
Place of publication Basel, Switzerland
Publisher MDPI
Collection year 2013
Language eng
Abstract Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine knot arrangement of three conserved disulfide bonds. This article provides an overview of the reported pesticidal or toxic activities of cyclotides, discusses a possible common mechanism of action involving disruption of biological membranes in pest species, and describes methods that can be used to produce cyclotides for potential applications as novel pesticidal agents.
Keyword Circular protein
Cyclic peptide
Cystine knot
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Insecticidal Toxins

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 34 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 19 Jul 2012, 09:02:31 EST by Susan Allen on behalf of Institute for Molecular Bioscience