Spider-venom peptides as bioinsecticides

Windley, Monique J., Herzig, Volker, Dziemborowicz, Sławomir A., Hardy, Margaret C., King, Glenn F. and Nicholson, Graham M. (2012) Spider-venom peptides as bioinsecticides. Toxins, 4 3: 191-227. doi:10.3390/toxins4030191

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Author Windley, Monique J.
Herzig, Volker
Dziemborowicz, Sławomir A.
Hardy, Margaret C.
King, Glenn F.
Nicholson, Graham M.
Total Author Count Override 6
Title Spider-venom peptides as bioinsecticides
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2012-03-22
Sub-type Article (original research)
DOI 10.3390/toxins4030191
Open Access Status DOI
Volume 4
Issue 3
Start page 191
End page 227
Total pages 37
Place of publication Basel, Switzerland
Publisher MDPI
Collection year 2013
Language eng
Abstract Over 10,000 arthropod species are currently considered to be pest organisms. They are estimated to contribute to the destruction of ~14% of the world’s annual crop production and transmit many pathogens. Presently, arthropod pests of agricultural and health significance are controlled predominantly through the use of chemical insecticides. Unfortunately, the widespread use of these agrochemicals has resulted in genetic selection pressure that has led to the development of insecticide-resistant arthropods, as well as concerns over human health and the environment. Bioinsecticides represent a new generation of insecticides that utilise organisms or their derivatives (e.g., transgenic plants, recombinant baculoviruses, toxin-fusion proteins and peptidomimetics) and show promise as environmentally-friendly alternatives to conventional agrochemicals. Spider-venom peptides are now being investigated as potential sources of bioinsecticides. With an estimated 100,000 species, spiders are one of the most successful arthropod predators. Their venom has proven to be a rich source of hyperstable insecticidal mini-proteins that cause insect paralysis or lethality through the modulation of ion channels, receptors and enzymes. Many newly characterized insecticidal spider toxins target novel sites in insects. Here we review the structure and pharmacology of these toxins and discuss the potential of this vast peptide library for the discovery of novel bioinsecticides.
Keyword Spider venom
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Insecticidal Toxins

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 18 Jul 2012, 17:53:30 EST by Professor Glenn King on behalf of School of Chemistry & Molecular Biosciences