Reduced N400 semantic priming effects in adult survivors of paediatric and adolescent traumatic brain injury

Knuepffer, C., Murdoch, B. E., Lloyd, D., Lewis, F. M. and Hinchliffe, F. J. (2012) Reduced N400 semantic priming effects in adult survivors of paediatric and adolescent traumatic brain injury. Brain and Language, 123 1: 52-63. doi:10.1016/j.bandl.2012.06.009


Author Knuepffer, C.
Murdoch, B. E.
Lloyd, D.
Lewis, F. M.
Hinchliffe, F. J.
Title Reduced N400 semantic priming effects in adult survivors of paediatric and adolescent traumatic brain injury
Journal name Brain and Language   Check publisher's open access policy
ISSN 0093-934X
1090-2155
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1016/j.bandl.2012.06.009
Open Access Status
Volume 123
Issue 1
Start page 52
End page 63
Total pages 12
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2013
Language eng
Abstract The immediate and long-term neural correlates of linguistic processing deficits reported following paediatric and adolescenttraumaticbraininjury (TBI) are poorly understood. Therefore, the current research investigated event-related potentials (ERPs) elicited during a semantic picture–word priming experiment in two groups of highly functioning individuals matched for various demographic variables and behavioural language performance. Participants in the TBI group had a recorded history of paediatric or adolescent TBI involving injury mechanisms associated with diffuse white matter pathology, while participants in the control group never sustained any insult to the brain. A comparison of N400 Mean Amplitudes elicited during three experimental conditions with varying semantic relatedness between the prime and target stimuli (congruent, semantically related, unrelated) revealed a significantly smaller N400 response in the unrelated condition in the TBI group, indicating residual linguistic processing deviations when processing demands required the quick detection of a between-category (unrelated) violation of semantic expectancy.
Keyword Paediatric
Traumatic brain injury
Diffuse axonal injury
Event-related potential
Semantic priming
N400
Long-term outcomes
Language
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Wed, 18 Jul 2012, 13:58:50 EST by Dr Fiona Lewis on behalf of School of Health & Rehabilitation Sciences