A blueprint for staging of murine melanocytic lesions based on the Cdk4 R24C/R24C :: Tyr- NRAS Q 61K model

Wurm, Elisabeth M.T., Lin, Lynlee L., Ferguson, Blake, Lambie, Duncan, Prow, Tarl W., Walker, Graeme J. and Soyer, H. Peter (2012) A blueprint for staging of murine melanocytic lesions based on the Cdk4 R24C/R24C :: Tyr- NRAS Q 61K model. Experimental Dermatology, 21 9: 676-681. doi:10.1111/j.1600-0625.2012.01543.x

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Author Wurm, Elisabeth M.T.
Lin, Lynlee L.
Ferguson, Blake
Lambie, Duncan
Prow, Tarl W.
Walker, Graeme J.
Soyer, H. Peter
Title A blueprint for staging of murine melanocytic lesions based on the Cdk4 R24C/R24C :: Tyr- NRAS Q 61K model
Formatted title A blueprint for staging of murine melanocytic lesions based on the Cdk4 R24C/R24C :: Tyr- NRAS Q 61K model
Journal name Experimental Dermatology   Check publisher's open access policy
ISSN 0906-6705
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1111/j.1600-0625.2012.01543.x
Volume 21
Issue 9
Start page 676
End page 681
Total pages 6
Place of publication Oxford, England, United Kingdom
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Formatted abstract It has been shown that gene mutations which drive the development of malignant melanoma (MM) in humans also lead to emergence of MM when engineered mice. However, little attention has been paid to the clinical and histopathological features of melanocytic lesions and their natural history in a given mouse model. This knowledge is crucial to enable us to understand how engineered mutations influence the initiation and evolution of melanocytic lesions, and/or for the use of mice as a preclinical model to test specific treatments. We recently reported the development of melanocytic proliferations along the spectrum of naevi to MM in a Cdk4 R24C/R24C: Tyr- NRAS Q 61K mouse model. In this study, we followed the development of lesions over time using digital photography and dermoscopy with the aim to correlate the clinical and histopathological features of lesions developing in this model. We identified two types of lesions. The first are slow-growing dermal MMs that emanate from dermal naevi. The second did not emanate from naevi, grew rapidly, and appeared to be solely confined to the subcutaneous fat. We present a simple staging system for the MMs that progress from naevi, based on depth of extension into the dermis and subcutis. This represents a blueprint for documentation and follow-up of MMs in the live animal, which is critical for the proper use of murine melanoma models.
Keyword Histopathology
Melanoma
Mouse models
Naevi
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 29 June 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Created: Mon, 16 Jul 2012, 23:21:09 EST by Matthew Lamb on behalf of School of Medicine