Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation

Yerkovich, Stephanie T., Chang, Anne B., Carroll, Melanie L., Petsky, Helen L., Scrivener, Greta and Upham, John W. (2012) Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation. Respirology, 17 5: 841-846. doi:10.1111/j.1440-1843.2012.02174.x

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Author Yerkovich, Stephanie T.
Chang, Anne B.
Carroll, Melanie L.
Petsky, Helen L.
Scrivener, Greta
Upham, John W.
Title Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation
Journal name Respirology   Check publisher's open access policy
ISSN 1440-1843
Publication date 2012-07
Sub-type Article (original research)
DOI 10.1111/j.1440-1843.2012.02174.x
Volume 17
Issue 5
Start page 841
End page 846
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2013
Language eng
Formatted abstract
Background and objective: The soluble receptor for advanced glycation end products (sRAGE) plays an important role in inflammation. Few studies have looked at sRAGE levels in human lungs, and there is no information in children. Therefore, this study aimed to compare bronchoalveolar lavage fluid (BALF) and plasma sRAGE concentrations in children in relation to age and inflammation.

Methods: BAL was performed in 76 children, and BALF and plasma sRAGE levels were determined by enzyme-linked immunosorbent assay.

Results: sRAGE levels were fourfold higher in BALF than in plasma (P < 0.001). BALF sRAGE was inversely proportional to age (r = -0.333, P = 0.008) and serum immunoglobulin A (r = -0.283, P = 0.028). Plasma sRAGE showed a positive correlation to the percentage of BAL macrophages and negative correlation to the percentage of neutrophils and lymphocytes (P < 0.05). Multivariate linear regression analysis identified that the percentage of BAL lymphocytes and neutrophils were significant independent predictors of plasma sRAGE levels, while age and the percentage of BAL macrophages independently predicted BALF sRAGE levels.

Conclusions: In children, sRAGE is present at higher concentrations in the lung compared with blood. It appears that sRAGE varies with age, and hence future studies of sRAGE in paediatric lung disease require age matching. The significant relationship between sRAGE and lung inflammation warrants further research. The sRAGE plays an important role in inflammation. This study identified that sRAGE is present at higher concentrations in the lung compared with blood of children, is developmentally regulated and varies with the pattern of lung inflammation.
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Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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Created: Wed, 11 Jul 2012, 13:41:43 EST by Matthew Lamb on behalf of School of Medicine