The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD

Matthews, Natasha, Vance, Alasdair, Cummins, Tarrant D. R., Wagner, Joeseph, Connolly, Amanda, Yamada, Jacqueline, Lockhart, Paul J., Panwar, Ajay, Wallace, Robyn H. and Bellgrove, Mark A. (2012) The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD. Behavioral and Brain Functions, 8 25.1-25.9. doi:10.1186/1744-9081-8-25

Author Matthews, Natasha
Vance, Alasdair
Cummins, Tarrant D. R.
Wagner, Joeseph
Connolly, Amanda
Yamada, Jacqueline
Lockhart, Paul J.
Panwar, Ajay
Wallace, Robyn H.
Bellgrove, Mark A.
Title The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD
Journal name Behavioral and Brain Functions   Check publisher's open access policy
ISSN 1744-9081
Publication date 2012-05-28
Sub-type Article (original research)
DOI 10.1186/1744-9081-8-25
Open Access Status DOI
Volume 8
Start page 25.1
End page 25.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background: This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.
Methods: One hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investigated using regression models that controlled for age, IQ, gender and medication status on the day of test.
Results: Significant associations were found between performance on the delayed-match-to-sample task and COMT genotype. More specifically, val/val homozygotes produced significantly more errors than did children who carried a least one met allele. There were no further associations between allelic variants and performance across the other working memory tasks.
Conclusions: The working memory measures employed in the present study differed in the degree to which accurate task performance depended upon either the dynamic updating and/or manipulation of items in working memory, as in the spatial span and spatial working memory tasks, or upon the stable maintenance of representations, as in the delay-match-to-sample task. The results are interpreted as evidence of a relationship between tonic dopamine levels associated with the met COMT allele and the maintenance of stable working memory representations required to perform the delayed-match-to-sample-task.
Keyword Attention-deficit-hyperactivity-disorder
Working memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 25

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Created: Tue, 10 Jul 2012, 16:23:38 EST by Debra McMurtrie on behalf of Queensland Brain Institute