Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice

Greferath, Ursula, Bennie, Antoinette, Kourakis, Angela, Bartlett, Perry F., Murphy, Mark and Barrett, Graham L. (2000) Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice. European Journal of Neuroscience, 12 3: 885-893. doi:10.1046/j.1460-9568.2000.00976.x

Author Greferath, Ursula
Bennie, Antoinette
Kourakis, Angela
Bartlett, Perry F.
Murphy, Mark
Barrett, Graham L.
Title Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2000-03
Sub-type Article (original research)
DOI 10.1046/j.1460-9568.2000.00976.x
Volume 12
Issue 3
Start page 885
End page 893
Total pages 9
Place of publication Malden, MA, United States
Publisher John Wiley & Sons
Language eng
Abstract The p75 low affinity neurotrophin receptor (p75) can induce apoptosis in various neuronal and glial cell types. Because p75 is expressed in the cholinergic neurons of the basal forebrain, p75 knockout mice may be expected to show an increased number of neurons in this region. Previous studies, however, have produced conflicting results, suggesting that genetic background and choice of control mice are critical. To try to clarify the conflicting results from previous reports, we undertook a further study of the basal forebrain in p75 knockout mice, paying particular attention to the use of genetically valid controls. The genetic backgrounds of p75 knockout and control mice used in this study were identical at 95% of loci. There was a small decrease in the number of cholinergic basal forebrain neurons in p75 knockout mice at four months of age compared with controls. This difference was no longer apparent at 15 months due to a reduction in numbers in control mice between the ages of 4 and 15 months. Cholinergic cell size in the basal forebrain was markedly increased in p75 knockout mice compared with controls. Spatial learning performance was consistently better in p75 knockout mice than in controls, and did not show any deterioration with age. The results indicate that p75 exerts a negative influence on the size of cholinergic forebrain neurons, but little effect on neuronal numbers. The markedly better spatial learning suggests that the function, as well as the size, of cholinergic neurons is negatively modulated by p75.
Keyword Apoptosis
Basal forebrain
Cholinergic neuron
p75 neurotrophin receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 56 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 57 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 10 Jul 2012, 15:59:16 EST by System User on behalf of Queensland Brain Institute