High specificity of combined narrow band imaging and autofluorescence mucosal assessment of patients with head and neck cancer

Nguyen, Phan, Bashirzadeh, Farzad, Hodge, Robert, Agnew, Julie, Farah, Camile S., Duhig, Edwina, Clarke, Belinda, Perry-Keene, Joanna, Botros, David, Masters, Ian Brent and Fielding, David (2012) High specificity of combined narrow band imaging and autofluorescence mucosal assessment of patients with head and neck cancer. Head and Neck, : .

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Author Nguyen, Phan
Bashirzadeh, Farzad
Hodge, Robert
Agnew, Julie
Farah, Camile S.
Duhig, Edwina
Clarke, Belinda
Perry-Keene, Joanna
Botros, David
Masters, Ian Brent
Fielding, David
Title High specificity of combined narrow band imaging and autofluorescence mucosal assessment of patients with head and neck cancer
Journal name Head and Neck  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012
Sub-type Article
DOI 10.1002/hed.22999
ISSN 1043-3074;1097-0347
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract Background
The purpose of this study was to evaluate combined autofluorescence (AF) and narrow band imaging (NBI) for detection of mucosal lesions additional to known primary head and neck cancers and to determine impact on management.

Methods
Patients with head and neck cancer requiring preoperative screening or posttreatment surveillance had white light (WL), AF and NBI inspection of the head and neck and bronchus. Known primary cancers were not analyzed, only additional lesions. Moderate dysplasia or worse was considered significant.

Results
In all, 73 patients were recruited. Respectively, there were 24 and 18 additional lesions in the head and neck and bronchus that had significant histopathology. In both regions, AF and NBI were more sensitive than WL for detecting significant dysplasia with NBI demonstrating better specificity than AF (p = .003); 11 of 73 patients (15.1%) had additional findings detected by AF and NBI, which had an impact on management.

Conclusion
Combined AF and NBI inspection is highly specific at panendoscopy and can influence management. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Keyword Head and neck cancer
Panendoscopy
Autofluorescence
Narrow band imaging
Field carcinogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 28 June 2012.

 
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Created: Tue, 10 Jul 2012, 15:45:35 EST by Matthew Lamb on behalf of School of Medicine