Activation of latent precursors in the hippocampus is dependent on long-term potentiation

Kameda M., Taylor C. J., Walker, T. L., Black, D. M., Abraham, W. C. and Bartlett, P. F. (2012) Activation of latent precursors in the hippocampus is dependent on long-term potentiation. Translational Psychiatry, 2 e72.1-e72.9. doi:10.1038/tp.2011.70

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Author Kameda M.
Taylor C. J.
Walker, T. L.
Black, D. M.
Abraham, W. C.
Bartlett, P. F.
Title Activation of latent precursors in the hippocampus is dependent on long-term potentiation
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2012-01
Sub-type Article (original research)
DOI 10.1038/tp.2011.70
Open Access Status DOI
Volume 2
Start page e72.1
End page e72.9
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract The recent discovery of a large latent population of precursor cells in the dentate gyrus of adult mice led us to investigate whether activation of this population is regulated by synaptic activity, thereby explaining the observation that environmental signals can affect neurogenesis. Using a variety of stimulation protocols, we found that only a long-term potentiation (LTP)-inducing protocol activated the latent precursor pool, leading to increased neurogenesis in the dentate gyrus. LTP induced by high-frequency stimulation (HFS) of the perforant pathway in vivo produced a two-fold increase in the number of neurospheres cultured from the stimulated hippocampus, compared with the unstimulated hippocampus. No increase in neurosphere number or neurogenesis was observed when the HFS failed to induce LTP. These results show that LTP can activate latent neural precursor cells in the adult mouse dentate gyrus, thereby providing a direct mechanism for regulating activity-driven neurogenesis. In the future, it may be possible to utilize such learning- or stimulation-induced neurogenesis to overcome disorders characterized by neuronal loss.
Keyword Dentate gyrus
Latent precursors
Long-term potentiation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e72

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Tue, 10 Jul 2012, 13:33:12 EST by Debra McMurtrie on behalf of Queensland Brain Institute