Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function

Rupasinghe, Darshani B., Knapp, Oliver, Blomster, Linda V., Schmid, Annina B., Adams, David J., King, Glenn F. and Ruitenberg, Marc J. (2012) Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function. Channels, 6 2: 103-110. doi:10.4161/chan.19484

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Author Rupasinghe, Darshani B.
Knapp, Oliver
Blomster, Linda V.
Schmid, Annina B.
Adams, David J.
King, Glenn F.
Ruitenberg, Marc J.
Title Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function
Formatted title
Localization of Na v1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function
Journal name Channels   Check publisher's open access policy
ISSN 1933-6950
1933-6969
Publication date 2012-03
Sub-type Article (original research)
DOI 10.4161/chan.19484
Volume 6
Issue 2
Start page 103
End page 110
Total pages 8
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Collection year 2013
Language eng
Formatted abstract
Loss-of-function mutations in the pore-forming α subunit of the voltage-gated sodium channel 1.7 (Na v1.7) cause congenital indifference to pain and anosmia. We used immunohistochemical techniques to study Na v1.7 localization in the rat olfactory system in order to better understand its role in olfaction. We confirm that Na v1.7 is expressed on olfactory sensory axons and report its presence on vomeronasal axons, indicating an important role for Na v1.7 in transmission of pheromonal cues. Following neuroepithelial injury, Na v1.7 was transiently expressed by cells of monocytic lineage. These findings support an emerging role for Na v1.7 in immune function. This sodium channel may provide an important pharmacological target for treatment of inflammatory injury and inflammatory pain syndromes.
Keyword Inflammation
Injury
Monocyte
Pain
Regeneration
Sodium channel
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 09 Jul 2012, 10:13:09 EST by System User on behalf of Institute for Molecular Bioscience