The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment

Skinner-Adams,Tina S., Butterworth, Alice S., Porter, Kimberly A., D'Amico, Ronald, Sawe, Fred, Shaffer, Doug, Siika, Abraham, Hosseinipour, Mina C., Stringer, Elizabeth, Currier, Judith S., Chipato, Tsungai, Salata, Robert, Lockman, Shahin, Eron, Joseph J., Meshnick, Steven R. and McCarthy, James S. (2012) The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment. PLoS One, 7 4 Article No. e34399: e34399-1-e34399-4. doi:10.1371/journal.pone.0034399


Author Skinner-Adams,Tina S.
Butterworth, Alice S.
Porter, Kimberly A.
D'Amico, Ronald
Sawe, Fred
Shaffer, Doug
Siika, Abraham
Hosseinipour, Mina C.
Stringer, Elizabeth
Currier, Judith S.
Chipato, Tsungai
Salata, Robert
Lockman, Shahin
Eron, Joseph J.
Meshnick, Steven R.
McCarthy, James S.
Title The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1371/journal.pone.0034399
Open Access Status DOI
Volume 7
Issue 4 Article No. e34399
Start page e34399-1
End page e34399-4
Total pages 4
Place of publication San Francisco CA , United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for ≥48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population
Keyword Plasmodium-Falciparum
Protease Inhibitors
In-Vitro
Hiv
Coinfection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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