Efficacy of tissue autofluorescence imaging (velscope) in the visualization of oral mucosal lesions

Farah, Camile S., McIntosh, Lidija, Georgiou, Anastasia and McCullough, Michael J. (2012) Efficacy of tissue autofluorescence imaging (velscope) in the visualization of oral mucosal lesions. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 6: 856-862. doi:10.1002/hed.21834


Author Farah, Camile S.
McIntosh, Lidija
Georgiou, Anastasia
McCullough, Michael J.
Title Efficacy of tissue autofluorescence imaging (velscope) in the visualization of oral mucosal lesions
Journal name Head and Neck-Journal for the Sciences and Specialties of the Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2012-06
Year available 2011
Sub-type Article (original research)
DOI 10.1002/hed.21834
Volume 34
Issue 6
Start page 856
End page 862
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
Background: Technology that highlights potentially malignant oral lesions in a highly sensitive and specific manner will aid clinicians in early diagnosis of these conditions. This study assessed the efficacy of direct tissue autofluorescence imaging Visually Enhanced Lesion Scope (VELScope) in the detection of oral mucosal lesions.

Methods: One hundred twelve patients referred with a potentially malignant oral mucosal lesion were examined under routine incandescent light, and then with VELScope, noting loss of autofluorescence and presence of blanching. Incisional biopsies were performed to provide definitive histopathological diagnoses.

Results: VELScope enhanced the visibility of 41 lesions and helped uncover 5 clinically undetected lesions. VELScope examination alone showed a sensitivity of 30% and a specificity of 63%. Its accuracy at identifying dysplasia was 55%.

Conclusion: VELScope examination cannot provide a definitive diagnosis regarding the presence of epithelial dysplasia. Loss of autofluorescence is not useful in diagnosing epithelial dysplasia in its own right without relevant clinical interpretation.
Keyword Oral cancer
Early detection
Oral examination
Tissue autofluorescence imaging
VELScope
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 4 August 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 02 Jul 2012, 08:29:24 EST by System User on behalf of School of Dentistry