Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?

Jhaveri, Dhanisha J., Taylor, Chanel J. and Bartlett, Perry F. (2012) Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?. Developmental Neurobiology, 72 7: 1044-1058. doi:10.1002/dneu.22027


Author Jhaveri, Dhanisha J.
Taylor, Chanel J.
Bartlett, Perry F.
Title Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?
Journal name Developmental Neurobiology   Check publisher's open access policy
ISSN 1932-8451
1932-846X
Publication date 2012-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/dneu.22027
Open Access Status DOI
Volume 72
Issue 7
Start page 1044
End page 1058
Total pages 15
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Abstract Resident populations of stem and precursor cells drive the production of new neurons in the adult hippocampus. Recent discoveries have highlighted that a large proportion of these precursor cells are in fact quiescent and can be activated by distinct neuronal activity under both normal physiological and pathological conditions. As growing evidence indicates that newborn neurons play a critical role in cognitive functions such as learning and memory and in mood regulation, it is paramount that we obtain a better understanding of how the reservoirs of stem and precursor cells are maintained and activated. In this review, we critically examine the roles of key molecular mechanisms that have been shown to regulate hippocampal precursor cells, especially their activation. We believe that understanding the mechanistic details of the activity-driven regulation of precursor cells will equip us with the ability to develop tailored strategies to trigger the generation of new neurons, thereby improving the functional outcomes in various neurological and psychiatric conditions.
Keyword Adult neurogenesis
Hippocampus
Neural precursor cell
Neural stem cell
Quiescent
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 9 June 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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