Exercise training in chronic kidney disease patients

Howden, Erin J., Fassett, Robert G., Isbel, Nicole M. and Coombes, Jeff S. (2012) Exercise training in chronic kidney disease patients. Sports Medicine, 42 6: 473-488. doi:10.2165/11630800-000000000-00000

Author Howden, Erin J.
Fassett, Robert G.
Isbel, Nicole M.
Coombes, Jeff S.
Title Exercise training in chronic kidney disease patients
Journal name Sports Medicine   Check publisher's open access policy
ISSN 0112-1642
Publication date 2012-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2165/11630800-000000000-00000
Volume 42
Issue 6
Start page 473
End page 488
Total pages 16
Place of publication Auckland, New Zealand
Publisher Adis International
Collection year 2013
Language eng
Abstract Chronic kidney disease (CKD) is a major public health problem that affects an estimated 1.7 million Australians. Patients with CKD commonly progress to end-stage kidney disease (ESKD) requiring dialysis andor kidney transplantation. They are at high risk of cardiovascular disease and many die from this prior to reaching ESKD. Few therapies are available to slow CKD progression and reduce cardiovascular morbidity and mortality. The benefit of exercise training has been well demonstrated in a range of disease conditions including ESKD and was recently highlighted by a systematic review in haemodialysis patients and a recent Cochrane review of all stages of CKD. However, the effects of exercise training in patients with CKD have not been extensively investigated. Our systematic search of the literature found only ten clinical trials in this area. The aim of this review is to review these studies, and to discuss the findings, safety considerations and suggest future areas of research. Overall, the majority of the studies are small, non-randomized, non-controlled trials. They have found that exercise training can increase exercise capacity, improve muscle strength and function, decrease blood pressure, and improve inflammation and oxidative stress biomarkers. The effects of exercise training on kidney function, cardiovascular disease and quality of life are unknown. Studies are needed to answer these questions and develop evidence-based exercise training guidelines for individuals with CKD.
Keyword Stage Renal-Disease
Clinical Cardiology
Hypertensive Rats
Aerobic Exercise
Oxidative Stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Created: Mon, 02 Jul 2012, 07:43:51 EST by System User on behalf of School of Human Movement and Nutrition Sciences