PTPN22 alters the development of regulatory T cells in the thymus

Maine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S. and Sherman, Linda A. (2012) PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology, 188 11: 5267-5275. doi:10.4049/jimmunol.1200150


Author Maine, Christian J.
Hamilton-Williams, Emma E.
Cheung, Jocelyn
Stanford, Stephanie M.
Bottini, Nunzio
Wicker, Linda S.
Sherman, Linda A.
Title PTPN22 alters the development of regulatory T cells in the thymus
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1550-6606
Publication date 2012-06-01
Sub-type Article (original research)
DOI 10.4049/jimmunol.1200150
Volume 188
Issue 11
Start page 5267
End page 5275
Total pages 9
Place of publication Bethesda, MD, United States
Publisher American Association of Immunologists
Collection year 2013
Language eng
Abstract PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs), we examined the effect of murine PTPN22 deficiency on Treg development and function. In the thymus, numbers of pre-Tregs and Tregs increased inversely with the level of PTPN22. This increase in Tregs persisted in the periphery and could play a key part in the reduced severity observed in the PTPN22-deficient mice of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. This could explain the lack of association of certain autoimmune conditions with PTPN22 risk alleles.
Keyword Tyrosine phosphatase PTPN22
Crohns disease
Self-peptide
620w allele
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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