Corneal sensitivity is related to established measures of diabetic peripheral neuropathy

Pritchard, Nicola, Edwards, Katie, Vagenas, Dimitrios, Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan (2012) Corneal sensitivity is related to established measures of diabetic peripheral neuropathy. Clinical and Experimental Optometry, 95 3: 355-361. doi:10.1111/j.1444-0938.2012.00729.x


Author Pritchard, Nicola
Edwards, Katie
Vagenas, Dimitrios
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Title Corneal sensitivity is related to established measures of diabetic peripheral neuropathy
Journal name Clinical and Experimental Optometry   Check publisher's open access policy
ISSN 0816-4622
1444-0938
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1111/j.1444-0938.2012.00729.x
Volume 95
Issue 3
Start page 355
End page 361
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Formatted abstract
Purpose:  The objective was to investigate the association between corneal sensitivity and established measures of diabetic peripheral neuropathy (DPN).

Methods: 
Corneal sensitivity was measured in 93 individuals with diabetes, 146 diabetic individuals without neuropathy and 61 control individuals without diabetes or neuropathy using a non-contact corneal aesthesiometer at the baseline visit of a five-year longitudinal natural history study of DPN. The correlation between corneal sensitivity and established measures of neuropathy was estimated and multi-dimensional scaling was used to represent similarities and dissimilarities between variables.

Results:
  The corneal sensitivity threshold was significantly correlated with a majority of established measures of DPN. Correlation coefficients ranged from -0.32 to 0.26. Using multi-dimensional scaling, non-contact corneal aesthesiometry was closer to the neuropathy disability score, diabetic neuropathy symptom score and Neuropad and most dissimilar to electrophysiological parameters and quantitative sensory testing.

Conclusion: 
Corneal sensitivity, although not strongly related, is associated with other functional measures of DPN and might provide a useful adjunct in identifying functional loss of small nerve fibre integrity.
Keyword Aesthesiometry
Cornea
Corneal sensitivity
Diabetes
Diabetic neuropathy
Non-contact corneal aesthesiometry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This special issue on Diabetes and the Eye has been co-ordinated by Professor Nathan Efron and Associate Professor Erica Fletcher

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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